Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.
Identifieur interne : 000137 ( Main/Exploration ); précédent : 000136; suivant : 000138Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.
Auteurs : Chloé Chrétien [France] ; Claire Fenech [France] ; Fabienne Liénard [France] ; Sylvie Grall [France] ; Charlène Chevalier [France] ; Sylvie Chaudy [France] ; Xavier Brenachot [France] ; Raymond Berges [France] ; Katie Louche [France] ; Romana Stark [Australie] ; Emmanuelle Nédélec [France] ; Amélie Laderrière [France] ; Zane B. Andrews [Australie] ; Alexandre Benani [France] ; Veit Flockerzi [Allemagne] ; Jean Gascuel [France] ; Jana Hartmann [Allemagne] ; Cédric Moro [France] ; Lutz Birnbaumer [États-Unis] ; Corinne Leloup [France] ; Luc Pénicaud [France] ; Xavier Fioramonti [France]Source :
- Diabetes [ 1939-327X ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Canaux cationiques TRPC (génétique), Canaux cationiques TRPC (métabolisme), Consommation alimentaire (génétique), Glucose (métabolisme), Homéostasie, Hyperglycémie provoquée, Hypothalamus (cytologie), Hypothalamus (métabolisme), Insuline (sécrétion), Jeûne, Mâle, Métabolisme énergétique (génétique), Neurones (métabolisme), Poids du corps (génétique), Rat Sprague-Dawley, Rats, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée C57BL, Technique de Western.
- MESH :
- cytologie : Hypothalamus.
- génétique : Canaux cationiques TRPC, Consommation alimentaire, Métabolisme énergétique, Poids du corps.
- métabolisme : Canaux cationiques TRPC, Glucose, Hypothalamus, Neurones.
- sécrétion : Insuline.
- Animaux, Homéostasie, Hyperglycémie provoquée, Jeûne, Mâle, Rat Sprague-Dawley, Rats, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée C57BL, Technique de Western.
English descriptors
- KwdEn :
- Animals, Blotting, Western, Body Weight (genetics), Eating (genetics), Energy Metabolism (genetics), Fasting, Glucose (metabolism), Glucose Tolerance Test, Homeostasis, Hypothalamus (cytology), Hypothalamus (metabolism), Insulin (secretion), Male, Mice, Mice, Inbred C57BL, Neurons (metabolism), Rats, Rats, Sprague-Dawley, Real-Time Polymerase Chain Reaction, TRPC Cation Channels (genetics), TRPC Cation Channels (metabolism).
- MESH :
- chemical , genetics : TRPC Cation Channels.
- chemical , metabolism : Glucose, TRPC Cation Channels.
- cytology : Hypothalamus.
- genetics : Body Weight, Eating, Energy Metabolism.
- metabolism : Hypothalamus, Neurons.
- chemical , secretion : Insulin.
- Animals, Blotting, Western, Fasting, Glucose Tolerance Test, Homeostasis, Male, Mice, Mice, Inbred C57BL, Rats, Rats, Sprague-Dawley, Real-Time Polymerase Chain Reaction.
Abstract
The mediobasal hypothalamus (MBH) contains neurons capable of directly detecting metabolic signals such as glucose to control energy homeostasis. Among them, glucose-excited (GE) neurons increase their electrical activity when glucose rises. In view of previous work, we hypothesized that transient receptor potential canonical type 3 (TRPC3) channels are involved in hypothalamic glucose detection and the control of energy homeostasis. To investigate the role of TRPC3, we used constitutive and conditional TRPC3-deficient mouse models. Hypothalamic glucose detection was studied in vivo by measuring food intake and insulin secretion in response to increased brain glucose level. The role of TRPC3 in GE neuron response to glucose was studied by using in vitro calcium imaging on freshly dissociated MBH neurons. We found that whole-body and MBH TRPC3-deficient mice have increased body weight and food intake. The anorectic effect of intracerebroventricular glucose and the insulin secretory response to intracarotid glucose injection are blunted in TRPC3-deficient mice. TRPC3 loss of function or pharmacological inhibition blunts calcium responses to glucose in MBH neurons in vitro. Together, the results demonstrate that TRPC3 channels are required for the response to glucose of MBH GE neurons and the central effect of glucose on insulin secretion and food intake.
DOI: 10.2337/db16-1114
PubMed: 27899482
Affiliations:
- Allemagne, Australie, France, États-Unis
- Bavière, Bourgogne, Bourgogne-Franche-Comté, Caroline du Nord, District de Haute-Bavière, Midi-Pyrénées, Occitanie (région administrative)
- Dijon, Munich, Toulouse
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Le document en format XML
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Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Laderriere, Amelie" sort="Laderriere, Amelie" uniqKey="Laderriere A" first="Amélie" last="Laderrière">Amélie Laderrière</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. 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Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Flockerzi, Veit" sort="Flockerzi, Veit" uniqKey="Flockerzi V" first="Veit" last="Flockerzi">Veit Flockerzi</name><affiliation wicri:level="1"><nlm:affiliation>Experimental and Clinical Pharmacology and Toxicology, Saarland University School of Medicine, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Pharmacology and Toxicology, Saarland University School of Medicine, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Gascuel, Jean" sort="Gascuel, Jean" uniqKey="Gascuel J" first="Jean" 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xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Moro, Cedric" sort="Moro, Cedric" uniqKey="Moro C" first="Cédric" last="Moro">Cédric Moro</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Birnbaumer, Lutz" sort="Birnbaumer, Lutz" uniqKey="Birnbaumer L" first="Lutz" last="Birnbaumer">Lutz Birnbaumer</name><affiliation wicri:level="2"><nlm:affiliation>Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Leloup, Corinne" sort="Leloup, Corinne" uniqKey="Leloup C" first="Corinne" last="Leloup">Corinne Leloup</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Penicaud, Luc" sort="Penicaud, Luc" uniqKey="Penicaud L" first="Luc" last="Pénicaud">Luc Pénicaud</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Fioramonti, Xavier" sort="Fioramonti, Xavier" uniqKey="Fioramonti X" first="Xavier" last="Fioramonti">Xavier Fioramonti</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France xavier.fioramonti@inra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement 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type="wicri:Area/Main/Exploration">000137</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.</title><author><name sortKey="Chretien, Chloe" sort="Chretien, Chloe" uniqKey="Chretien C" first="Chloé" last="Chrétien">Chloé Chrétien</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Fenech, Claire" sort="Fenech, Claire" uniqKey="Fenech C" first="Claire" last="Fenech">Claire Fenech</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Lienard, Fabienne" sort="Lienard, Fabienne" uniqKey="Lienard F" first="Fabienne" last="Liénard">Fabienne Liénard</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Grall, Sylvie" sort="Grall, Sylvie" uniqKey="Grall S" first="Sylvie" last="Grall">Sylvie Grall</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Chevalier, Charlene" sort="Chevalier, Charlene" uniqKey="Chevalier C" first="Charlène" last="Chevalier">Charlène Chevalier</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Chaudy, Sylvie" sort="Chaudy, Sylvie" uniqKey="Chaudy S" first="Sylvie" last="Chaudy">Sylvie Chaudy</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Brenachot, Xavier" sort="Brenachot, Xavier" uniqKey="Brenachot X" first="Xavier" last="Brenachot">Xavier Brenachot</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Berges, Raymond" sort="Berges, Raymond" uniqKey="Berges R" first="Raymond" last="Berges">Raymond Berges</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Louche, Katie" sort="Louche, Katie" uniqKey="Louche K" first="Katie" last="Louche">Katie Louche</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Stark, Romana" sort="Stark, Romana" uniqKey="Stark R" first="Romana" last="Stark">Romana Stark</name><affiliation wicri:level="1"><nlm:affiliation>Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Department of Physiology, Monash University, Clayton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Department of Physiology, Monash University, Clayton, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Nedelec, Emmanuelle" sort="Nedelec, Emmanuelle" uniqKey="Nedelec E" first="Emmanuelle" last="Nédélec">Emmanuelle Nédélec</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Laderriere, Amelie" sort="Laderriere, Amelie" uniqKey="Laderriere A" first="Amélie" last="Laderrière">Amélie Laderrière</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. Andrews</name><affiliation wicri:level="1"><nlm:affiliation>Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Department of Physiology, Monash University, Clayton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Department of Physiology, Monash University, Clayton, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Benani, Alexandre" sort="Benani, Alexandre" uniqKey="Benani A" first="Alexandre" last="Benani">Alexandre Benani</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Flockerzi, Veit" sort="Flockerzi, Veit" uniqKey="Flockerzi V" first="Veit" last="Flockerzi">Veit Flockerzi</name><affiliation wicri:level="1"><nlm:affiliation>Experimental and Clinical Pharmacology and Toxicology, Saarland University School of Medicine, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Pharmacology and Toxicology, Saarland University School of Medicine, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Gascuel, Jean" sort="Gascuel, Jean" uniqKey="Gascuel J" first="Jean" last="Gascuel">Jean Gascuel</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Hartmann, Jana" sort="Hartmann, Jana" uniqKey="Hartmann J" first="Jana" last="Hartmann">Jana Hartmann</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Moro, Cedric" sort="Moro, Cedric" uniqKey="Moro C" first="Cédric" last="Moro">Cédric Moro</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Birnbaumer, Lutz" sort="Birnbaumer, Lutz" uniqKey="Birnbaumer L" first="Lutz" last="Birnbaumer">Lutz Birnbaumer</name><affiliation wicri:level="2"><nlm:affiliation>Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Leloup, Corinne" sort="Leloup, Corinne" uniqKey="Leloup C" first="Corinne" last="Leloup">Corinne Leloup</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Penicaud, Luc" sort="Penicaud, Luc" uniqKey="Penicaud L" first="Luc" last="Pénicaud">Luc Pénicaud</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Fioramonti, Xavier" sort="Fioramonti, Xavier" uniqKey="Fioramonti X" first="Xavier" last="Fioramonti">Xavier Fioramonti</name><affiliation wicri:level="3"><nlm:affiliation>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon, France xavier.fioramonti@inra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Centre des Sciences du Goût et de l'Alimentation, CNRS, Institut National de la Recherche Agronomique, University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author></analytic><series><title level="j">Diabetes</title><idno type="eISSN">1939-327X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Body Weight (genetics)</term><term>Eating (genetics)</term><term>Energy Metabolism (genetics)</term><term>Fasting</term><term>Glucose (metabolism)</term><term>Glucose Tolerance Test</term><term>Homeostasis</term><term>Hypothalamus (cytology)</term><term>Hypothalamus (metabolism)</term><term>Insulin (secretion)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neurons (metabolism)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Real-Time Polymerase Chain Reaction</term><term>TRPC Cation Channels (genetics)</term><term>TRPC Cation Channels (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Canaux cationiques TRPC (génétique)</term><term>Canaux cationiques TRPC (métabolisme)</term><term>Consommation alimentaire (génétique)</term><term>Glucose (métabolisme)</term><term>Homéostasie</term><term>Hyperglycémie provoquée</term><term>Hypothalamus (cytologie)</term><term>Hypothalamus (métabolisme)</term><term>Insuline (sécrétion)</term><term>Jeûne</term><term>Mâle</term><term>Métabolisme énergétique (génétique)</term><term>Neurones (métabolisme)</term><term>Poids du corps (génétique)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Technique de Western</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>TRPC Cation Channels</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term><term>TRPC Cation Channels</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Hypothalamus</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hypothalamus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Weight</term><term>Eating</term><term>Energy Metabolism</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux cationiques TRPC</term><term>Consommation alimentaire</term><term>Métabolisme énergétique</term><term>Poids du corps</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypothalamus</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canaux cationiques TRPC</term><term>Glucose</term><term>Hypothalamus</term><term>Neurones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="sécrétion" xml:lang="fr"><term>Insuline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Fasting</term><term>Glucose Tolerance Test</term><term>Homeostasis</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Homéostasie</term><term>Hyperglycémie provoquée</term><term>Jeûne</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Technique de Western</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mediobasal hypothalamus (MBH) contains neurons capable of directly detecting metabolic signals such as glucose to control energy homeostasis. Among them, glucose-excited (GE) neurons increase their electrical activity when glucose rises. In view of previous work, we hypothesized that transient receptor potential canonical type 3 (TRPC3) channels are involved in hypothalamic glucose detection and the control of energy homeostasis. To investigate the role of TRPC3, we used constitutive and conditional TRPC3-deficient mouse models. Hypothalamic glucose detection was studied in vivo by measuring food intake and insulin secretion in response to increased brain glucose level. The role of TRPC3 in GE neuron response to glucose was studied by using in vitro calcium imaging on freshly dissociated MBH neurons. We found that whole-body and MBH TRPC3-deficient mice have increased body weight and food intake. The anorectic effect of intracerebroventricular glucose and the insulin secretory response to intracarotid glucose injection are blunted in TRPC3-deficient mice. TRPC3 loss of function or pharmacological inhibition blunts calcium responses to glucose in MBH neurons in vitro. Together, the results demonstrate that TRPC3 channels are required for the response to glucose of MBH GE neurons and the central effect of glucose on insulin secretion and food intake.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Bavière</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Caroline du Nord</li><li>District de Haute-Bavière</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Dijon</li><li>Munich</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Chretien, Chloe" sort="Chretien, Chloe" uniqKey="Chretien C" first="Chloé" last="Chrétien">Chloé Chrétien</name></region><name sortKey="Benani, Alexandre" sort="Benani, Alexandre" uniqKey="Benani A" first="Alexandre" last="Benani">Alexandre Benani</name><name sortKey="Berges, Raymond" sort="Berges, Raymond" uniqKey="Berges R" first="Raymond" last="Berges">Raymond Berges</name><name sortKey="Brenachot, Xavier" sort="Brenachot, Xavier" uniqKey="Brenachot X" first="Xavier" last="Brenachot">Xavier Brenachot</name><name sortKey="Chaudy, Sylvie" sort="Chaudy, Sylvie" uniqKey="Chaudy S" first="Sylvie" last="Chaudy">Sylvie Chaudy</name><name sortKey="Chevalier, Charlene" sort="Chevalier, Charlene" uniqKey="Chevalier C" first="Charlène" last="Chevalier">Charlène Chevalier</name><name sortKey="Fenech, Claire" sort="Fenech, Claire" uniqKey="Fenech C" first="Claire" last="Fenech">Claire Fenech</name><name sortKey="Fioramonti, Xavier" sort="Fioramonti, Xavier" uniqKey="Fioramonti X" first="Xavier" last="Fioramonti">Xavier Fioramonti</name><name sortKey="Gascuel, Jean" sort="Gascuel, Jean" uniqKey="Gascuel J" first="Jean" last="Gascuel">Jean Gascuel</name><name sortKey="Grall, Sylvie" sort="Grall, Sylvie" uniqKey="Grall S" first="Sylvie" last="Grall">Sylvie Grall</name><name sortKey="Laderriere, Amelie" sort="Laderriere, Amelie" uniqKey="Laderriere A" first="Amélie" last="Laderrière">Amélie Laderrière</name><name sortKey="Leloup, Corinne" sort="Leloup, Corinne" uniqKey="Leloup C" first="Corinne" last="Leloup">Corinne Leloup</name><name sortKey="Lienard, Fabienne" sort="Lienard, Fabienne" uniqKey="Lienard F" first="Fabienne" last="Liénard">Fabienne Liénard</name><name sortKey="Louche, Katie" sort="Louche, Katie" uniqKey="Louche K" first="Katie" last="Louche">Katie Louche</name><name sortKey="Moro, Cedric" sort="Moro, Cedric" uniqKey="Moro C" first="Cédric" last="Moro">Cédric Moro</name><name sortKey="Nedelec, Emmanuelle" sort="Nedelec, Emmanuelle" uniqKey="Nedelec E" first="Emmanuelle" last="Nédélec">Emmanuelle Nédélec</name><name sortKey="Penicaud, Luc" sort="Penicaud, Luc" uniqKey="Penicaud L" first="Luc" last="Pénicaud">Luc Pénicaud</name></country><country name="Australie"><noRegion><name sortKey="Stark, Romana" sort="Stark, Romana" uniqKey="Stark R" first="Romana" last="Stark">Romana Stark</name></noRegion><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. Andrews</name></country><country name="Allemagne"><noRegion><name sortKey="Flockerzi, Veit" sort="Flockerzi, Veit" uniqKey="Flockerzi V" first="Veit" last="Flockerzi">Veit Flockerzi</name></noRegion><name sortKey="Hartmann, Jana" sort="Hartmann, Jana" uniqKey="Hartmann J" first="Jana" last="Hartmann">Jana Hartmann</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Birnbaumer, Lutz" sort="Birnbaumer, Lutz" uniqKey="Birnbaumer L" first="Lutz" last="Birnbaumer">Lutz Birnbaumer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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